Integrative Metabolic Therapy for Cancer Treatment with HBOT
1. Foundational Principles
Metabolic Theory of Cancer:
All cancer thrives in a hypoxic (low-oxygen), acidic microenvironment with dysfunctional mitochondrial energy production (Warburg effect).
Treatment Goal: Disrupt cancer’s metabolic flexibility by restoring oxygen homeostasis, improving mitochondrial function, and depriving tumors of fermentable fuels (e.g., glucose/glutamine).
Key Mechanisms of HBOT:
Saturates tissues with oxygen, reversing hypoxia and acidosis.
Enhances mitochondrial respiration, shifting cells away from glycolysis.
Reduces inflammation and potentiates chemo/radiation efficacy.
2. Metabolic Treatment Protocol
A. Dietary Strategy:
Ketogenic Diet:
Macronutrient ratio: 70–80% fat, 15–20% protein, 5–10% carbs.
Target blood ketones: 3–5 mmol/L (monitored via ketometer).
Avoid glucose-spiking foods (High Carbs)
Time-Restricted Eating (TRE):
16:8 fasting window (e.g., eat between 12 PM–8 PM).
24–48-hour fasts monthly (if tolerated, under supervision).
12-Week Protocol
| Phase | Weeks 1–4 | Weeks 5–8 | Weeks 9–12 |
|---|---|---|---|
| Hyperbaric chambe (HBOT) | 5x/week (2.0 ATA, 90m) | 3x/week (2.2 ATA, 90m) | 2x/week (2.4 ATA, 60m) |
| Diet | Ketogenic diet + 48-hour fasting monthly | Ketogenic diet + 48-hour fasting monthly | Eat Healthy |
| Supplements | Acivicin | Acivicin +Add berberine/curcumin | Vitamin C |
| Monitoring | Baseline labs/imaging | Midpoint PET-CT | Final assessment |
